Review Article
Open access
Peer reviewed
Mechanobiological Interactions in Microorganisms: Implications for Host-Pathogen Dynamics and Antibiotic Resistance
- Department of Microbiology, Skyline University, Nigeria
- Department of Chemistry and Molecular Biology, University of Gothenburg, Sweden
- Department of Chemistry, Howard University, Washington DC, USA
- Department of Chemistry, Nottingham Trent University, UK
- Department of Medicinal Research, Kaohsiung Medical University Hospital, Taiwan
- Department of Biochemistry, Skyline University, Nigeria
- Department of Microbiology, Kwara State University, Malete, Nigeria
- Received
- Published
DOI
https://doi.org/10.55006/biolsciences.2025.5302
How to Cite
Biological Sciences, Vol. 5 No. 3 (2025), 963-977
Abstract
The interplay between mechanical forces and biological systems, particularly within microorganisms, has emerged as a critical factor influencing pathogen behavior and host-pathogen interactions. This study explores the role of mechanobiology—how mechanical forces such as shear stress, deformation, and surface tension affect microbial dynamics—within the context of infection and antibiotic resistance. This study discusses how mechanical stimuli regulate microbial adhesion, biofilm formation, and virulence, with direct implications for antibiotic resistance. By integrating insights from physics, biology, and microbiology, the study provides a novel perspective on how these forces could influence pathogen survival and resistance mechanisms, such as the formation of protective biofilms or the induction of stress-responsive genetic pathways. While the article offers valuable insights into the mechanobiology of pathogens, it presents several gaps that warrant further investigation. These include the underexplored role of host tissue mechanics in shaping microbial pathogenesis, the genetic adaptations of pathogens to mechanical stresses, and the potential for developing novel therapeutic approaches that target mechanobiological pathways. Future research in this field should aim to bridge the gap between physical forces, microbial genetics, and immune responses, offering new strategies for combating antibiotic-resistant infections. In sum, this study highlights the need for a more integrated approach to understanding microbial infections, one that incorporates the growing field of mechanobiology into conventional therapeutic and preventative paradigms.
Downloads
Most read articles by the same author(s)
- Mustapha Abdulsalam, Ibrahim Abdulrazaq, Bashir Bolaji Tiamiyu, Olaitan Lateefat Salam, Comparative Antimicrobial Properties of a Consortium of Nauclea latifolia Sm. and Ocimum gratissium L. Extracts with Their CuO , Biological Sciences: Vol. 3 No. 1 (2023): Volume 3, Issue 1 (March)
- Mustapha Abdulsalam, Musa Ojeba Innocent, Miracle Uwa Livinus, Fatimoh Abdulsalam Danjuma, Idowu Afeez Temitope, Ishola Jonathan Adekunle, Hydroxychloroquine and Azithromycin in Treating Emerging Viral Infections: Efficacy, Safety, and Mechanisms in Monkeypox and Influenza A (H5N1) , Biological Sciences: Vol. 5 No. 1 (2025): Volume 5, Issue 1 (March)
- Fiddausi Umar Musa, Tijani Abiola Tajudeen, Olaitan Lateefat Salam, Idowu Afeez Temitope, Miracle Uwa Livinus, Abdulhakeem Idris Abdulhakeem, Ishola Jonathan Adekunle, Musa Ojeba Innocent, Mustapha Abdulsalam, Environmental Epidemiology Reimagined: Soil Microbes as Indicators of Public Health Risks , Biological Sciences: Vol. 5 No. 3 (2025): Volume 5, Issue 3 (September)
- Fatima Abdulkadir Muhammad, Shehu-Alimi Elelu, Ganiyat Omotayo Ibrahim, Idowu Afeez Temitope, Miracle Uwa Livinus, Abdulsalam Hawau Avoswahi, Alege Abdulraheem Lateefat, Musa Ojeba Innocent, Mustapha Abdulsalam, Artificial Intelligence Meets Vascular Health: Identifying Molecules for Precision Repair of Barrier Dysfunctions , Biological Sciences: Vol. 5 No. 2 (2025): Volume 5, Issue 2 (June)
- Mustapha Abdulsalam, Exploring the Therapeutic Promise of Cationic Antibacterial Peptides , Biological Sciences: Vol. 4 No. 3 (2024): Volume 4, Issue 3 (September)
- Mustapha Abdulsalam, Musa Ojeba Innocent, Miracle Uwa Livinus, Fatimoh Abdulsalam Danjuma, Idowu Afeez Temitope, Ishola Jonathan Adekunle, XEC: The Next Frontier in COVID-19 Evolution and Biotechnological Interventions , Biological Sciences: Vol. 5 No. 4 (2025): Volume 5, Issue 4 (December)
- Mustapha Abdulsalam, Ojeba Innocent Musa, Miracle Uwa Livinus, Amosa Sulyman Olayinka, Adewale Opeyemi Ajibola, Maryam Ibrahim Aminu, Imam Muzeenat Oyinkansola, Single-Cell Multi-Omics Uncovers the Role of Microbiota-Derived Metabolites in Shaping the Epigenetic Landscape of Neural Stem Cells during Aging , Biological Sciences: Vol. 6 No. 2 (2026): Volume 6, Issue 2 (June)
