Review Article
Open access
Peer reviewed
Microbial Magic: Decoding the Impact of Hypoxia on Exercise Physiology through Microbiota Dynamics
- Department of Microbiology, Skyline University Nigeria
- Department of Physiotherapy, Skyline University Nigeria
- Received
- Published
DOI
https://doi.org/10.55006/biolsciences.2024.4308
Citation
Biological Sciences, Vol. 4 No. 3 (2024), 736-745
Abstract
This study explores the intricate interplay between microbiota, hypoxia-induced physiological adaptations, and exercise physiology. In a time where understanding the nuanced connections between microbial communities and human health is gaining prominence. The present study fills a significant research gap by exploring the processes by which microbiota modification alters physiological responses to hypoxic environments during exercise. The objective of this study is to disentangle the microbial metabolic discourse that unfurls in the context of hypoxia-induced physiological adaptations, thereby shedding light on potential avenues for enhancing exercise performance and optimizing health outcomes. This study presents a synthesis of existing knowledge to discern significant patterns and insights. This study divulges the multifaceted relationships between microbiota composition, host metabolism, immune responses, and exercise-induced hypoxic adaptations by analyzing the existing work. The findings of this analysis highlight the crucial job of microbiota in modulating host responses to hypoxia, impacting metabolic pathways, oxygen transport, and cellular signaling. This study contributes to the advancing field of exercise physiology by elucidating the intricate connections between microbial communities and hypoxia-induced physiological adaptations. It emphasizes the significance of considering the microbiota as an integral component of the exercise response, opening up new avenues for innovative strategies to optimize exercise outcomes.
References
- 1. Sherwood, L. (2015). Human physiology: From cells to systems. Cengage Learning, 1(9):23.
- 2. Gebrayel, P., Nicco, C., Al Khodor, S., Bilinski, J., Caselli, E., Comelli, E. M. (2022). Microbiota medicine: Towards clinical revolution. Journal of Translational Medicine, 20(1), 1-20.
- 3. Askew, E. W. (2002). Work at high altitude and oxidative stress: Antioxidant nutrients. Toxicology, 180(2), 107-119.
- 4. Cani, P. D., & Delzenne, N. M. (2009). The role of the gut microbiota in energy metabolism and metabolic disease. Current Pharmaceutical Design, 15(13), 1546-1558.
- 5. Aragón-Vela, J., Solis-Urra, P., Ruiz-Ojeda, F. J., Álvarez-Mercado, A. I., Olivares-Arancibia, J., & Plaza-Diaz, J. (2021). Impact of exercise on gut microbiota in obesity. Nutrients, 13(11), 3999.
- 6. Lin, W., Djukovic, A., Mathur, D., & Xavier, J. B. (2021). Listening in on the conversation between the human gut microbiome and its host. Current Opinion in Microbiology, 63, 150-157.
- 7. Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012). The impact of the gut microbiota on human health: An integrative view. Cell, 148(6), 1258-1270.
- 8. Belizário, J. E., & Napolitano, M. (2015). Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approaches. Frontiers in Microbiology, 6, 1050.
- 9. Lundby, C., Montero, D., & Joyner, M. (2017). Biology of VO2max: Looking under the physiology lamp. Acta Physiologica, 220(2), 218-228.
- 10. Abdulsalam, M., Ubah, F. Z. Y., Ahmed, H. U., Tafida, U. A., & Nasir, A. W. (2024). Deciphering the Genetic Code: Mechanisms, Evolution, and Implications for Biotechnology. World Journal of Advanced Research and Reviews, 21(1), 858-868.
- 11. Brooks, G. A. (2009). Cell-cell and intracellular lactate shuttles. The Journal of Physiology, 587(23), 5591-5600.
- 12. Pialoux, V., Mounier, R., Ponsot, E., Rock, E., Mazur, A., Dufour, S. (2006). Effects of exercise and training in hypoxia on antioxidant/pro-oxidant balance. European Journal of Clinical Nutrition, 60(12), 1345-1354.
- 13. Travers, G., Kippelen, P., Trangmar, S. J., & González-Alonso, J. (2022). Physiological function during exercise and environmental stress in humans—An integrative view of body systems and homeostasis. Cells, 11(3), 383.
- 14. Saheed, Y. K., Balogun, B. F., Odunayo, B. J., & Mustapha, A. (2023). Microarray Gene Expression Data Classification Via Wilcoxon Sign Rank Sum and Novel Grey Wolf Optimized Ensemble Learning Models. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 20(6), 3575-3587.
- 15. Zilber-Rosenberg, I., & Rosenberg, E. (2008). Role of microorganisms in the evolution of animals and plants: The hologenome theory of evolution. FEMS Microbiology Reviews, 32(5), 723-735.
- 16. Marchesi, J. R., Adams, D. H., Fava, F., Hermes, G. D., Hirschfield, G. M., Hold, G. (2016). The gut microbiota and host health: A new clinical frontier. Gut, 65(2), 330-339.
- 17. Semenza, G. L. (2011). Oxygen sensing, homeostasis, and disease. The New England Journal of Medicine, 365(6), 537-547.
- 18. Murray, A. J., & Horscroft, J. A. (2016). Mitochondrial function at extremely high altitudes. The Journal of Physiology, 594(5), 1137-1149.
- 19. David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E. (2014). Diet rapidly and reproducibly alters the human gut microbiome. Nature, 505(7484), 559-563.
- 20. Bronfenbrenner, U. (1977). Toward an experimental ecology of human development. American Psychologist, 32(7), 513.
- 21. Bronfenbrenner, U. (1979). The ecology of human development: Experiments by nature and design. Harvard University Press, 2, 139-163.
- 22. Macke, E., Tasiemski, A., Massol, F., Callens, M., & Decaestecker, E. (2017). Life history and eco‐evolutionary dynamics in light of the gut microbiota. Oikos, 126(4), 508-531.
- 23. Sallis, J. F., Owen, N., & Fisher, E. (2015). Ecological models of health behavior. In K. Glanz, B. K. Rimer, & K. Viswanath (Eds.), Health behavior: Theory, research, and practice (5th ed., pp. 43-64). Jossey-Bass.
- 24. Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., Antes, G., & Tugwell, P. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement (Chinese edition). Journal of Chinese Integrative Medicine, 7(9), 889-896.
- 25. Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009). Bacterial community variation in human body habitats across space and time. Science, 326(5960), 1694-1697.
- 26. Queipo-Ortuño, M. I., Seoane, L. M., Murri, M., Pardo, M., Gomez-Zumaquero, J. M., Cardona, F. (2013). Gut microbiota composition in male rat models under different nutritional status and physical activity and its association with serum leptin and ghrelin levels. PLoS One, 8(5), e65465.
- 27. Mailing, L. J., Allen, J. M., Buford, T. W., Fields, C. J., & Woods, J. A. (2019). Exercise and the gut microbiome: A review of the evidence, potential mechanisms, and implications for human health. Exercise and Sport Sciences Reviews, 47(2), 75-85.
- 28. Maiese, K. (2023). Cellular metabolism: A fundamental component of degeneration in the nervous system. Biomolecules, 13(5), 816.
- 29. Bruick, R. K., & McKnight, S. L. (2002). Oxygen sensing gets a second wind. Science, 295(5556), 807-808.
- 30. Sampsell, K., Hao, D., & Reimer, R. A. (2022). The gut microbiota: A potential gateway to improved health outcomes in breast cancer treatment and survivorship. International Journal of Molecular Sciences, 23(1), 9239.
- 31. Saheed, Y. K., Salau-Ibrahim, T. T., Abdulsalam, M., Adeniji, I. A., & Balogun, B. F. (2024). Modified bi-directional long short-term memory and hyperparameter tuning of supervised machine learning models for cardiovascular heart disease prediction in the mobile cloud environment. Biomedical Signal Processing and Control, 94, 106319.
- 32. Huang, L., Li, T., Zhou, M., Deng, M., Zhang, L., Yi, L., (2022). Hypoxia improves endurance performance by enhancing short-chain fatty acid production via gut microbiota remodeling. Frontiers in Microbiology, 12, 820691.
- 33. Yoo, J. Y., Groer, M., Dutra, S. V. O., Sarkar, A., & McSkimming, D. I. (2020). Gut microbiota and immune system interactions. Microorganisms, 8(10), 1587.
- 34. Huang, Y., Liu, J., Tun, H. M., Stanton, C., Chen, T., El-Nezami, H. (2022). Gut microbiota insights into human adaptation to high-plateau diet. iMeta, 1(1).
- 35. Keirns, B. H., Koemel, N. A., Sciarrillo, C. M., Anderson, K. L., & Emerson, S. R. (2020). Exercise and intestinal permeability: Another form of exercise-induced hormesis? American Journal of Physiology-Gastrointestinal and Liver Physiology, 319(4), G512-G518.
- 36. Leser, T. D., & Mølbak, L. (2009). Better living through microbial action: The benefits of the mammalian gastrointestinal microbiota on the host. Environmental Microbiology, 11(9), 2194-2206.
- 37. Liu, K., Yang, J., & Yuan, H. (2021). Recent progress in research on the gut microbiota and highland adaptation on the Qinghai‐Tibet Plateau. Journal of Evolutionary Biology, 34(10), 1514-1530.
- 38. Mohr, A. E., Jäger, R., Carpenter, K. C., Kerksick, C. M., Purpura, M., Townsend, J. R., (2020). The athletic gut microbiota. Journal of the International Society of Sports Nutrition, 17(1), 1-33.
- 39. Ticinesi, A., Lauretani, F., Tana, C., Nouvenne, A., Ridolo, E., & Meschi, T. (2019). Exercise and immune system as modulators of intestinal microbiome: implications for the gut-muscle axis hypothesis. Exercise immunology review, 25:84-95.
- 40. Khan, S., Moore, R. J., Stanley, D., & Chousalkar, K. K. (2020). The gut microbiota of laying hens and its manipulation with prebiotics and probiotics to enhance gut health and food safety. Applied and environmental microbiology, 86(13), e00600-20.
Downloads
Most read articles by the same author(s)
- Mustapha Abdulsalam, Aisha Abba Hamisu, Aisha Musa Ahmad, Fatima Balarabe Wakili, Fatima Sulaiman Annu, Maryam Murtala Garba, Microbiome Dynamics and Strategic Management Strategies: Exploring Synergies between Integrative Medicine Modalities and Microbial Balance , Biological Sciences: Vol. 4 No. 3 (2024): Volume 4, Issue 3 (September)
- Halima Ahmad Gwadabe, Shehu-Alimi Elelu, Musa Ojeba Innocent, Ganiyat Omotayo Ibrahim, Ishola Jonathan Adekunle, Mustapha Abdulsalam, Exploring Local-to-Global Win-Win Strategies for Infectious Disease Control: Enhancing Human Health and Sustainability , Biological Sciences: Vol. 5 No. 1 (2025): Volume 5, Issue 1 (March)
- Mustapha Abdulsalam, Mujtaba Amina Ila, Closing the Gap: Artificial Intelligence Integration for Advancing Chikungunya Virus Studies in Africa , Biological Sciences: Vol. 3 No. 4 (2023): Volume 3, Issue 4 (December)
- Aisha Ameera Abdullah, Shehu-Alimi Elelu, Musa Ojeba Innocent, Ganiyat Omotayo Ibrahim, Tijani Abiola Tajudeen, Umar Abdulrasheed, Mustapha Abdulsalam, Advances in Mushroom Chitosan Biorefinery and Its Applications in Food Engineering: A Sustainable Approach to Food Preservation and Quality Enhancement , Biological Sciences: Vol. 5 No. 1 (2025): Volume 5, Issue 1 (March)
- Amina Abdulhamid Ahmed, Ummulkhair Adamu Yusuf, Zainab Hussein Fadlallah, Musa Ojeba Innocent, Mustapha Abdulsalam, Developing an Omics-Driven Computational Framework for Next-Generation Microbiome Therapeutics , Biological Sciences: Vol. 4 No. 4 (2024): Volume 4, Issue 4 (December)
- Mustapha Abdulsalam, Aisha Abba Hamisu, Aisha Musa Ahmad, Fatima Balarabe Wakili, Iman Bala Rabiu, Rukayya Ahmad Burodo, Fatima Bala Bello, Fatima Yusuf Aliyu, Hajara Ali Yanmusa, Nana Aisha Iliyas, Synergies at the Intersection: Exploring the Role of Bioinformatics in Enhancing Physiotherapy and Nursing Practice , Biological Sciences: Vol. 4 No. 3 (2024): Volume 4, Issue 3 (September)
- Ibrahim Abdulrazaq, Shehu-Alimi Elelu, Ganiyat Omotayo Ibrahim, Idowu Afeez Temitope, Abdulsalam Hawau Avoswahi, Abdulkareem Tajuddeen Zakari, Mustapha Abdulsalam, Advancements in Microbial Drug Discovery: Leveraging AI, CRISPR, and Microbiome Insights to Overcome Antimicrobial Resistance , Biological Sciences: Vol. 5 No. 3 (2025): Volume 5, Issue 3 (September)
- Tijani Abiola Tajudeen, Olaitan Lateefat Salam, Idowu Afeez Temitope, Abdulhakeem Idris Abdulhakeem, Ishola Jonathan Adekunle, Musa Ojeba Innocent, Mustapha Abdulsalam, Exploration of Soil Microbiomes as a Source of Novel Antimicrobial Compounds for Combating Drug-Resistant Pathogens , Biological Sciences: Vol. 5 No. 3 (2025): Volume 5, Issue 3 (September)
- Abdulazizu Bala, Shehu-Alimi Elelu, Ganiyat Omotayo Ibrahim, Idowu Afeez Temitope, Miracle Uwa Livinus, Abdullahi Mustapha Yasir, Musa Ojeba Innocent, Mustapha Abdulsalam, Peptide-Based Approaches for Biomolecule Encapsulation, Storage, and Preservation: A Comprehensive Review , Biological Sciences: Vol. 5 No. 2 (2025): Volume 5, Issue 2 (June)
- Mustapha Abdulsalam, Ibrahim Abdulrazaq, Bashir Bolaji Tiamiyu, Olaitan Lateefat Salam, Comparative Antimicrobial Properties of a Consortium of Nauclea latifolia Sm. and Ocimum gratissium L. Extracts with Their CuO , Biological Sciences: Vol. 3 No. 1 (2023): Volume 3, Issue 1 (March)